You are here

Home

JavaScript

In computing, JavaScript is a high-level, dynamic, untyped, and interpreted programming language. [Source: Wikipedia ]

TargetExpress

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Mammalian genomes encode for thousands of microRNAs, which can potentially regulate the majority of protein-coding genes. They have been implicated in development and disease, leading to great interest in understanding their function, with computational methods being widely used to predict their targets. Most computational methods rely on sequence features, thermodynamics, and conservation filters; essentially scanning the whole transcriptome to predict one set of targets for each microRNA.

Rating: 
Average: 5 (1 vote)

Infinity

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

miRNAs are potent regulators of gene expression and modulate multiple cellular processes in physiology and pathology. Deregulation of miRNAs expression has been found in various cancer types, thus, miRNAs may be potential targets for cancer therapy. However, the mechanisms through which miRNAs are regulated in cancer remain unclear. Therefore, the identification of transcriptional factor-miRNA crosstalk is one of the most update aspects of the study of miRNAs regulation.

Rating: 
Average: 5 (1 vote)

GermlncRNA

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Spermatogenic failure is a major cause of male infertility, which affects millions of couples worldwide. Recent discovery of long non-coding RNAs (lncRNAs) as critical regulators in normal and disease development provides new clues for delineating the molecular regulation in male germ cell development. However, few functional lncRNAs have been characterized to date. A major limitation in studying lncRNA in male germ cell development is the absence of germ cell-specific lncRNA annotation.

Rating: 
Average: 5 (1 vote)

BCIP

Submitted by ChenLiang on Thu, 04/06/2017 - 17:28

Breast cancer is a disease with high heterogeneity. Many issues on tumorigenesis and progression are still elusive. It is critical to identify genes that play important roles in the progression of tumors, especially for tumors with poor prognosis such as basal-like breast cancer and tumors in very young women. To facilitate the identification of potential regulatory or driver genes, we present the Breast Cancer Integrative Platform (BCIP, http://omics.bmi.ac.cn/bcancer/).

Rating: 
3
Average: 3 (2 votes)

ARN (Autophagy)

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Autophagy is a complex cellular process having multiple roles, depending on tissue, physiological, or pathological conditions. Major post-translational regulators of autophagy are well known, however, they have not yet been collected comprehensively. The precise and context-dependent regulation of autophagy necessitates additional regulators, including transcriptional and post-transcriptional components that are listed in various datasets.

Rating: 
5
Average: 4.5 (2 votes)

ViralmiR

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

microRNAs (miRNAs) play a vital role in development, oncogenesis, and apoptosis by binding to mRNAs to regulate the posttranscriptional level of coding genes in mammals, plants, and insects. Recent studies have demonstrated that the expression of viral miRNAs is associated with the ability of the virus to infect a host. Identifying potential viral miRNAs from experimental sequence data is valuable for deciphering virus-host interactions. Thus far, a specific predictive model for viral miRNA identification has yet to be developed.

Rating: 
Average: 5 (1 vote)

QuickMIRSeq

Submitted by ChenLiang on Thu, 04/06/2017 - 18:50

Genome-wide miRNA expression data can be used to study miRNA dysregulation comprehensively. Although many open-source tools for microRNA (miRNA)-seq data analyses are available, challenges remain in accurate miRNA quantification from large-scale miRNA-seq dataset. We implemented a pipeline called QuickMIRSeq for accurate quantification of known miRNAs and miRNA isoforms (isomiRs) from multiple samples simultaneously.

Rating: 
Average: 5 (1 vote)

UP-TORR

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

RNA interference (RNAi) is a widely adopted tool for loss-of-function studies but RNAi results only have biological relevance if the reagents are appropriately mapped to genes. Several groups have designed and generated RNAi reagent libraries for studies in cells or in vivo for Drosophila and other species. At first glance, matching RNAi reagents to genes appears to be a simple problem, as each reagent is typically designed to target a single gene. In practice, however, the reagent-gene relationship is complex.

Rating: 
Average: 5 (1 vote)

miREC

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Endometrial cancer (EC) is the most frequently diagnosed gynecological malignancy and the fourth most common cancer diagnosis overall among women. As with many other forms of cancer, it has been shown that certain miRNAs are differentially expressed in EC and these miRNAs are believed to play important roles as regulators of processes involved in the development of the disease.

Rating: 
Average: 5 (1 vote)

GeneHub-GEPIS

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

GeneHub-GEPIS is a web application that performs digital expression analysis in human and mouse tissues based on an integrated gene database. Using aggregated expressed sequence tag (EST) library information and EST counts, the application calculates the normalized gene expression levels across a large panel of normal and tumor tissues, thus providing rapid expression profiling for a given gene.

Rating: 
Average: 5 (1 vote)

Pages

Subscribe to JavaScript