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In computing, JavaScript is a high-level, dynamic, untyped, and interpreted programming language. [Source: Wikipedia ]

miRpower

Submitted by ChenLiang on Fri, 10/21/2016 - 16:39

PURPOSE: The proper validation of prognostic biomarkers is an important clinical issue in breast cancer research. MicroRNAs (miRNAs) have emerged as a new class of promising breast cancer biomarkers. In the present work, we developed an integrated online bioinformatic tool to validate the prognostic relevance of miRNAs in breast cancer. METHODS: A database was set up by searching the GEO, EGA, TCGA, and PubMed repositories to identify datasets with published miRNA expression and clinical data.

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PlaMoM

Submitted by ChenLiang on Mon, 01/09/2017 - 11:29

In plants, various phloem-mobile macromolecules including noncoding RNAs, mRNAs and proteins are suggested to act as important long-distance signals in regulating crucial physiological and morphological transition processes such as flowering, plant growth and stress responses. Given recent advances in high-throughput sequencing technologies, numerous mobile macromolecules have been identified in diverse plant species from different plant families.

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BCCTBbp

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

BCCTBbp (http://bioinformatics.breastcancertissuebank.org) was initially developed as the data-mining portal of the Breast Cancer Campaign Tissue Bank (BCCTB), a vital resource of breast cancer tissue for researchers to support and promote cutting-edge research.

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SlideBase

Submitted by ChenLiang on Mon, 01/09/2017 - 11:33

Genomics consortia have produced large datasets profiling the expression of genes, micro-RNAs, enhancers and more across human tissues or cells. There is a need for intuitive tools to select subsets of such data that is the most relevant for specific studies. To this end, we present SlideBase, a web tool which offers a new way of selecting genes, promoters, enhancers and microRNAs that are preferentially expressed/used in a specified set of cells/tissues, based on the use of interactive sliders.

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Exp. Verified microRNA-Target

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Recent studies have indicated that microRNA (miRNA) may play an oncogenic or tumor suppressor role in human cancer. To study the regulatory role of miRNAs in tumorigenesis, an integrated platform has been set up to provide a user friendly interface for query. The main advantage of the present platform is that all the miRNA target genes' information and disease records are drawn from experimentally verified or high confidence records.

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miRDis

Submitted by ChenLiang on Fri, 01/13/2017 - 10:33

Small RNA sequencing is the most widely used tool for microRNA (miRNA) discovery, and shows great potential for the efficient study of miRNA cross-species transport, i.e., by detecting the presence of exogenous miRNA sequences in the host species. Because of the increased appreciation of dietary miRNAs and their far-reaching implication in human health, research interests are currently growing with regard to exogenous miRNAs bioavailability, mechanisms of cross-species transport and miRNA function in cellular biological processes.

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comTAR

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

MicroRNAs (miRNAs) are major regulators of gene expression in plants and animals. They recognize their target messenger RNAs (mRNAs) by sequence complementarity and guide them to cleavage or translational arrest. So far, the prediction of plant miRNA-target pairs generally relies on the use of empirical parameters deduced from known miRNA-target interactions.

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SNPLogic

Submitted by ChenLiang on Thu, 04/06/2017 - 19:12

SNPLogic (http://www.snplogic.org) brings together single nucleotide polymorphism (SNP) information from numerous sources to provide a comprehensive SNP selection, annotation and prioritization system for design and analysis of genotyping projects.

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miXGENE

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Contemporary molecular biology deals with wide and heterogeneous sets of measurements to model and understand underlying biological processes including complex diseases. Machine learning provides a frequent approach to build such models. However, the models built solely from measured data often suffer from overfitting, as the sample size is typically much smaller than the number of measured features. In this paper, we propose a random forest-based classifier that reduces this overfitting with the aid of prior knowledge in the form of a feature interaction network.

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Average: 5 (1 vote)

OfftargetFinder

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatic web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process.

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Average: 4.5 (2 votes)

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