You are here

Home

Active

MiRComb

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

MicroRNAs (miRNAs) are small RNAs that regulate the expression of target mRNAs by specific binding on the mRNA 3'UTR and promoting mRNA degradation in the majority of cases. It is often of interest to know the specific targets of a miRNA in order to study them in a particular disease context. In that sense, some databases have been designed to predict potential miRNA-mRNA interactions based on hybridization sequences. However, one of the main limitations is that these databases have too many false positives and do not take into account disease-specific interactions.

Rating: 
5
Average: 4.5 (2 votes)

miR-EdiTar

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

A-to-I RNA editing is an important mechanism that consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA)-mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones.

Rating: 
Average: 5 (1 vote)

miRMaster

Submitted by ChenLiang on Tue, 01/09/2018 - 17:27

Abstract is not available.[1]

Rating: 
Average: 5 (1 vote)

metaMIR

Submitted by ChenLiang on Tue, 01/09/2018 - 16:53

MicroRNAs (miRNAs) are key regulators of cell-fate decisions in development and disease with a vast array of target interactions that can be investigated using computational approaches. For this study, we developed metaMIR, a combinatorial approach to identify miRNAs that co-regulate identified subsets of genes from a user-supplied list. We based metaMIR predictions on an improved dataset of human miRNA-target interactions, compiled using a machine-learning-based meta-analysis of established algorithms.

Rating: 
Average: 5 (1 vote)

miRprimer

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

MicroRNAs are small but biologically important RNA molecules. Although different methods can be used for quantification of microRNAs, quantitative PCR is regarded as the reference that is used to validate other methods. Several commercial qPCR assays are available but they often come at a high price and the sequences of the primers are not disclosed. An alternative to commercial assays is to manually design primers but this work is tedious and, hence, not practical for the design of primers for a larger number of targets.

Rating: 
Average: 5 (1 vote)

HCCNet

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Abstract is not available.[1]

 

 

 

 

 

Rating: 
Average: 5 (1 vote)

Tools4miRs

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

MiRNAs are short, non-coding molecules that negatively regulate gene expression and thereby play several important roles in living organisms. Dozens of computational methods for miRNA-related research have been developed, which greatly differ in various aspects. The substantial availability of difficult-to-compare approaches makes it challenging for the user to select a proper tool and prompts the need for a solution that will collect and categorize all the methods.

Rating: 
Average: 5 (1 vote)

RiceChip

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Rice (Oryza sativa) feeds over half of the global population. A web-based integrated platform for rice microarray annotation and data analysis in various biological contexts is presented, which provides a convenient query for comprehensive annotation compared with similar databases. Coupled with existing rice microarray data, it provides online analysis methods from the perspective of bioinformatics.

Rating: 
Average: 5 (1 vote)

GED

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

Reproductive infertility affects seventh of couples, which is most attributed to the obstacle of gametogenesis. Characterizing the epigenetic modification factors involved in gametogenesis is fundamental to understand the molecular mechanisms and to develop treatments for human infertility. Although the genetic factors have been implicated in gametogenesis, no dedicated bioinformatics resource for gametogenesis is available.

Rating: 
Average: 5 (1 vote)

iSmaRT

Submitted by ChenLiang on Mon, 01/09/2017 - 13:33

The interest in investigating the biological roles of small non-coding RNAs (sncRNAs) is increasing, due to the pleiotropic effects of these molecules exert in many biological contexts. While several methods and tools are available to study microRNAs (miRNAs), only few focus on novel classes of sncRNAs, in particular PIWI-interacting RNAs (piRNAs). To overcome these limitations, we implemented iSmaRT (integrative Small RNA Tool-kit), an automated pipeline to analyze smallRNA-Seq data.

Rating: 
Average: 5 (1 vote)

Pages

Subscribe to Active