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Pathway

miRUPnet

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

With the rapid accumulation of microRNA (miRNAs), a class of newly identified small noncoding RNAs, in silico inference of miRNA functions has become one of the central tasks in miRNA bioinformatics. Traditional methods have helped in the understanding of miRNAs, but they also have limitations.

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CHRONOS

Submitted by ChenLiang on Fri, 09/02/2016 - 21:59

In the era of network medicine and the rapid growth of paired time series mRNA/microRNA expression experiments, there is an urgent need for pathway enrichment analysis methods able to capture the time- and condition-specific 'active parts' of the biological circuitry as well as the microRNA impact. Current methods ignore the multiple dynamical 'themes'-in the form of enriched biologically relevant microRNA-mediated subpathways-that determine the functionality of signaling networks across time.

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